The International Testicular Cancer Linkage Consortium: A Clinicopathologic Descriptive Analysis of 461 Familial Malignant Testicular Germ Cell Tumor Kindred
Identifieur interne : 007B52 ( Main/Exploration ); précédent : 007B51; suivant : 007B53The International Testicular Cancer Linkage Consortium: A Clinicopathologic Descriptive Analysis of 461 Familial Malignant Testicular Germ Cell Tumor Kindred
Auteurs : Phuong L. Mai [États-Unis] ; Michael Friedlander [Australie] ; Kathy Tucker [Australie] ; Kelly-Anne Phillips [Australie] ; David Hogg [Canada] ; Michael A. S. Jewett [Canada] ; Radka Lohynska [République tchèque] ; Gedske Daugaard [Danemark] ; Stéphane Richard [France] ; Catherine Bonaïti-Pellié [France] ; Axel Heidenreich [Allemagne] ; Peter Albers [Allemagne] ; Istvan Bodrogi [Hongrie] ; Lajos Geczi [Hongrie] ; Edith Olah [Hongrie] ; Peter A. Daly [Irlande (pays)] ; Parry Guilford [Nouvelle-Zélande] ; Sophie D. Foss [Norvège] ; Ketil Heimdal [Norvège] ; Ludmila Liubchenko [Russie] ; Sergei A. Tjulandin [Russie] ; Hans Stoll [Suisse] ; Walter Weber [Suisse] ; Douglas F. Easton [Royaume-Uni] ; Darshna Dudakia [Royaume-Uni] ; Robert Huddart [Royaume-Uni] ; Michael R. Stratton [Royaume-Uni] ; Lawrence Einhorn [États-Unis] ; Larissa Korde [États-Unis] ; Katherine L. Nathanson [États-Unis] ; D. Timothy Bishop [Royaume-Uni] ; Elizabeth A. Rapley [Royaume-Uni] ; Mark H. Greene [États-Unis]Source :
- Urologic oncology [ 1078-1439 ] ; 2009.
Abstract
Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.
Families with ≥2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.
A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P=0.001). Among individuals with a history of cryptorchidism, TGCT was more likely to occur in the ipsilateral testis (kappa=0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.
Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for non-familial cases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation.
Url:
DOI: 10.1016/j.urolonc.2008.10.004
PubMed: 19162511
PubMed Central: 2891341
Affiliations:
- Allemagne, Australie, Canada, Danemark, France, Hongrie, Irlande (pays), Norvège, Nouvelle-Zélande, Royaume-Uni, Russie, République tchèque, Suisse, États-Unis
- Bohême centrale, District de Kassel, District fédéral central, Hesse (Land), Hongrie centrale, Hovedstaden, Maryland, Nouvelle-Galles du Sud, Ontario, Pennsylvanie, Østlandet
- Budapest, Cassel (Hesse), Copenhague, Moscou, Oslo, Prague, Sydney, Toronto
- Université de Toronto
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Jewett</name><affiliation wicri:level="4"><nlm:aff id="A4"> Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Princess Margaret Hospital and University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lohynska, Radka" sort="Lohynska, Radka" uniqKey="Lohynska R" first="Radka" last="Lohynska">Radka Lohynska</name><affiliation wicri:level="3"><nlm:aff id="A5"> University Hospital, Dept of Radiotherapy and Oncology, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea> University Hospital, Dept of Radiotherapy and Oncology, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Daugaard, Gedske" sort="Daugaard, Gedske" uniqKey="Daugaard G" first="Gedske" last="Daugaard">Gedske Daugaard</name><affiliation wicri:level="3"><nlm:aff id="A6"> Dept of Oncology, Rigshospitalet, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea> Dept of Oncology, Rigshospitalet, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Richard, Stephane" sort="Richard, Stephane" uniqKey="Richard S" first="Stéphane" last="Richard">Stéphane Richard</name><affiliation wicri:level="1"><nlm:aff id="A7"> Génétique Oncologique EPHE-CNRS FRE 2939 Faculté de Médecine Paris-Sud; Service d’Urologie, CHU, Le Kremlin-Bicêtre; Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Génétique Oncologique EPHE-CNRS FRE 2939 Faculté de Médecine Paris-Sud; Service d’Urologie, CHU, Le Kremlin-Bicêtre; Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Bonaiti Pellie, Catherine" sort="Bonaiti Pellie, Catherine" uniqKey="Bonaiti Pellie C" first="Catherine" last="Bonaïti-Pellié">Catherine Bonaïti-Pellié</name><affiliation wicri:level="1"><nlm:aff id="A8"> INSERM U 535, Villejuif, F-94817 France; Univ Paris-Sud, IFR 69, UMR-S535, Villejuif, F-94817 France</nlm:aff><country wicri:rule="zip">France</country><wicri:regionArea> INSERM U 535, Villejuif, F-94817 France; Univ Paris-Sud, IFR 69, UMR-S535, Villejuif, F-94817 France</wicri:regionArea><wicri:noRegion>94817 France</wicri:noRegion><wicri:noRegion>94817 France</wicri:noRegion></affiliation></author><author><name sortKey="Heidenreich, Axel" sort="Heidenreich, Axel" uniqKey="Heidenreich A" first="Axel" last="Heidenreich">Axel Heidenreich</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Urology, Division of Oncological Urology, University of Köln, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Urology, Division of Oncological Urology, University of Köln</wicri:regionArea><wicri:noRegion>University of Köln</wicri:noRegion><wicri:noRegion>University of Köln</wicri:noRegion><wicri:noRegion>University of Köln</wicri:noRegion></affiliation></author><author><name sortKey="Albers, Peter" sort="Albers, Peter" uniqKey="Albers P" first="Peter" last="Albers">Peter Albers</name><affiliation wicri:level="3"><nlm:aff id="A10"> Department of Urology, Klinikum Kassel GmbH, Moenchebergstr. 41-43, D-34125 Kassel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Urology, Klinikum Kassel GmbH, Moenchebergstr. 41-43, D-34125 Kassel</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Bodrogi, Istvan" sort="Bodrogi, Istvan" uniqKey="Bodrogi I" first="Istvan" last="Bodrogi">Istvan Bodrogi</name><affiliation wicri:level="3"><nlm:aff id="A11"> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Geczi, Lajos" sort="Geczi, Lajos" uniqKey="Geczi L" first="Lajos" last="Geczi">Lajos Geczi</name><affiliation wicri:level="3"><nlm:aff id="A11"> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation wicri:level="3"><nlm:aff id="A11"> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name><affiliation wicri:level="1"><nlm:aff id="A12"> Department of Medical Oncology, St James’s Hospital, Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Department of Medical Oncology, St James’s Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Guilford, Parry" sort="Guilford, Parry" uniqKey="Guilford P" first="Parry" last="Guilford">Parry Guilford</name><affiliation wicri:level="1"><nlm:aff id="A13"> Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea> Cancer Genetics Laboratory, University of Otago, Dunedin</wicri:regionArea><wicri:noRegion>Dunedin</wicri:noRegion></affiliation></author><author><name sortKey="Foss, Sophie D" sort="Foss, Sophie D" uniqKey="Foss S" first="Sophie D." last="Foss">Sophie D. Foss</name><affiliation wicri:level="3"><nlm:aff id="A14"> Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Heimdal, Ketil" sort="Heimdal, Ketil" uniqKey="Heimdal K" first="Ketil" last="Heimdal">Ketil Heimdal</name><affiliation wicri:level="3"><nlm:aff id="A14"> Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Liubchenko, Ludmila" sort="Liubchenko, Ludmila" uniqKey="Liubchenko L" first="Ludmila" last="Liubchenko">Ludmila Liubchenko</name><affiliation wicri:level="3"><nlm:aff id="A15"> Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea> Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Tjulandin, Sergei A" sort="Tjulandin, Sergei A" uniqKey="Tjulandin S" first="Sergei A." last="Tjulandin">Sergei A. Tjulandin</name><affiliation wicri:level="3"><nlm:aff id="A15"> Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea> Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Stoll, Hans" sort="Stoll, Hans" uniqKey="Stoll H" first="Hans" last="Stoll">Hans Stoll</name><affiliation wicri:level="1"><nlm:aff id="A16"> Medical Oncology, University Hospital, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> Medical Oncology, University Hospital, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Walter" sort="Weber, Walter" uniqKey="Weber W" first="Walter" last="Weber">Walter Weber</name><affiliation wicri:level="1"><nlm:aff id="A16"> Medical Oncology, University Hospital, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> Medical Oncology, University Hospital, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="A17"> CRC Genetic Epidemiology Unit, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> CRC Genetic Epidemiology Unit, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Dudakia, Darshna" sort="Dudakia, Darshna" uniqKey="Dudakia D" first="Darshna" last="Dudakia">Darshna Dudakia</name><affiliation wicri:level="1"><nlm:aff id="A18"> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Huddart, Robert" sort="Huddart, Robert" uniqKey="Huddart R" first="Robert" last="Huddart">Robert Huddart</name><affiliation wicri:level="1"><nlm:aff id="A19"> Academic Radiotherapy Unit, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Academic Radiotherapy Unit, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><affiliation wicri:level="1"><nlm:aff id="A18"> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Einhorn, Lawrence" sort="Einhorn, Lawrence" uniqKey="Einhorn L" first="Lawrence" last="Einhorn">Lawrence Einhorn</name><affiliation wicri:level="1"><nlm:aff id="A20"> Department of Medicine, Indiana University School of Medicine, Indianapolis, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Medicine, Indiana University School of Medicine, Indianapolis</wicri:regionArea><wicri:noRegion>Indianapolis</wicri:noRegion></affiliation></author><author><name sortKey="Korde, Larissa" sort="Korde, Larissa" uniqKey="Korde L" first="Larissa" last="Korde">Larissa Korde</name><affiliation wicri:level="2"><nlm:aff id="A1"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="2"><nlm:aff id="A21"> Division of Medical Genetics, Department of Medicine, University of Pennsylvania School of Medicine, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Medical Genetics, Department of Medicine, University of Pennsylvania School of Medicine, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><affiliation wicri:level="1"><nlm:aff id="A22"> Imperial Cancer Research Fund Genetic Epidemiology Lab, Ashley Wing, Leeds, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Imperial Cancer Research Fund Genetic Epidemiology Lab, Ashley Wing, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Rapley, Elizabeth A" sort="Rapley, Elizabeth A" uniqKey="Rapley E" first="Elizabeth A." last="Rapley">Elizabeth A. Rapley</name><affiliation wicri:level="1"><nlm:aff id="A18"> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation wicri:level="2"><nlm:aff id="A1"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19162511</idno><idno type="pmc">2891341</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891341</idno><idno type="RBID">PMC:2891341</idno><idno type="doi">10.1016/j.urolonc.2008.10.004</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">001496</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001496</idno><idno type="wicri:Area/Pmc/Curation">001356</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001356</idno><idno type="wicri:Area/Pmc/Checkpoint">002713</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002713</idno><idno type="wicri:Area/Ncbi/Merge">000513</idno><idno type="wicri:Area/Ncbi/Curation">000513</idno><idno type="wicri:Area/Ncbi/Checkpoint">000513</idno><idno type="wicri:doubleKey">1078-1439:2009:Mai P:the:international:testicular</idno><idno type="wicri:Area/Main/Merge">008203</idno><idno type="wicri:Area/Main/Curation">007B52</idno><idno type="wicri:Area/Main/Exploration">007B52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The International Testicular Cancer Linkage Consortium: A Clinicopathologic Descriptive Analysis of 461 Familial Malignant Testicular Germ Cell Tumor Kindred</title><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation wicri:level="2"><nlm:aff id="A1"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name><affiliation wicri:level="3"><nlm:aff id="A2"> Dept of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Dept of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Tucker, Kathy" sort="Tucker, Kathy" uniqKey="Tucker K" first="Kathy" last="Tucker">Kathy Tucker</name><affiliation wicri:level="3"><nlm:aff id="A2"> Dept of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Dept of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name><affiliation wicri:level="4"><nlm:aff id="A4"> Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Princess Margaret Hospital and University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Jewett, Michael A S" sort="Jewett, Michael A S" uniqKey="Jewett M" first="Michael A. S." last="Jewett">Michael A. S. Jewett</name><affiliation wicri:level="4"><nlm:aff id="A4"> Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Princess Margaret Hospital and University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lohynska, Radka" sort="Lohynska, Radka" uniqKey="Lohynska R" first="Radka" last="Lohynska">Radka Lohynska</name><affiliation wicri:level="3"><nlm:aff id="A5"> University Hospital, Dept of Radiotherapy and Oncology, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea> University Hospital, Dept of Radiotherapy and Oncology, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Daugaard, Gedske" sort="Daugaard, Gedske" uniqKey="Daugaard G" first="Gedske" last="Daugaard">Gedske Daugaard</name><affiliation wicri:level="3"><nlm:aff id="A6"> Dept of Oncology, Rigshospitalet, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea> Dept of Oncology, Rigshospitalet, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Richard, Stephane" sort="Richard, Stephane" uniqKey="Richard S" first="Stéphane" last="Richard">Stéphane Richard</name><affiliation wicri:level="1"><nlm:aff id="A7"> Génétique Oncologique EPHE-CNRS FRE 2939 Faculté de Médecine Paris-Sud; Service d’Urologie, CHU, Le Kremlin-Bicêtre; Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Génétique Oncologique EPHE-CNRS FRE 2939 Faculté de Médecine Paris-Sud; Service d’Urologie, CHU, Le Kremlin-Bicêtre; Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Bonaiti Pellie, Catherine" sort="Bonaiti Pellie, Catherine" uniqKey="Bonaiti Pellie C" first="Catherine" last="Bonaïti-Pellié">Catherine Bonaïti-Pellié</name><affiliation wicri:level="1"><nlm:aff id="A8"> INSERM U 535, Villejuif, F-94817 France; Univ Paris-Sud, IFR 69, UMR-S535, Villejuif, F-94817 France</nlm:aff><country wicri:rule="zip">France</country><wicri:regionArea> INSERM U 535, Villejuif, F-94817 France; Univ Paris-Sud, IFR 69, UMR-S535, Villejuif, F-94817 France</wicri:regionArea><wicri:noRegion>94817 France</wicri:noRegion><wicri:noRegion>94817 France</wicri:noRegion></affiliation></author><author><name sortKey="Heidenreich, Axel" sort="Heidenreich, Axel" uniqKey="Heidenreich A" first="Axel" last="Heidenreich">Axel Heidenreich</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Urology, Division of Oncological Urology, University of Köln, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Urology, Division of Oncological Urology, University of Köln</wicri:regionArea><wicri:noRegion>University of Köln</wicri:noRegion><wicri:noRegion>University of Köln</wicri:noRegion><wicri:noRegion>University of Köln</wicri:noRegion></affiliation></author><author><name sortKey="Albers, Peter" sort="Albers, Peter" uniqKey="Albers P" first="Peter" last="Albers">Peter Albers</name><affiliation wicri:level="3"><nlm:aff id="A10"> Department of Urology, Klinikum Kassel GmbH, Moenchebergstr. 41-43, D-34125 Kassel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Urology, Klinikum Kassel GmbH, Moenchebergstr. 41-43, D-34125 Kassel</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Bodrogi, Istvan" sort="Bodrogi, Istvan" uniqKey="Bodrogi I" first="Istvan" last="Bodrogi">Istvan Bodrogi</name><affiliation wicri:level="3"><nlm:aff id="A11"> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Geczi, Lajos" sort="Geczi, Lajos" uniqKey="Geczi L" first="Lajos" last="Geczi">Lajos Geczi</name><affiliation wicri:level="3"><nlm:aff id="A11"> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation wicri:level="3"><nlm:aff id="A11"> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea> Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name><affiliation wicri:level="1"><nlm:aff id="A12"> Department of Medical Oncology, St James’s Hospital, Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Department of Medical Oncology, St James’s Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Guilford, Parry" sort="Guilford, Parry" uniqKey="Guilford P" first="Parry" last="Guilford">Parry Guilford</name><affiliation wicri:level="1"><nlm:aff id="A13"> Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea> Cancer Genetics Laboratory, University of Otago, Dunedin</wicri:regionArea><wicri:noRegion>Dunedin</wicri:noRegion></affiliation></author><author><name sortKey="Foss, Sophie D" sort="Foss, Sophie D" uniqKey="Foss S" first="Sophie D." last="Foss">Sophie D. Foss</name><affiliation wicri:level="3"><nlm:aff id="A14"> Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Heimdal, Ketil" sort="Heimdal, Ketil" uniqKey="Heimdal K" first="Ketil" last="Heimdal">Ketil Heimdal</name><affiliation wicri:level="3"><nlm:aff id="A14"> Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Liubchenko, Ludmila" sort="Liubchenko, Ludmila" uniqKey="Liubchenko L" first="Ludmila" last="Liubchenko">Ludmila Liubchenko</name><affiliation wicri:level="3"><nlm:aff id="A15"> Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea> Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Tjulandin, Sergei A" sort="Tjulandin, Sergei A" uniqKey="Tjulandin S" first="Sergei A." last="Tjulandin">Sergei A. Tjulandin</name><affiliation wicri:level="3"><nlm:aff id="A15"> Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea> Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Stoll, Hans" sort="Stoll, Hans" uniqKey="Stoll H" first="Hans" last="Stoll">Hans Stoll</name><affiliation wicri:level="1"><nlm:aff id="A16"> Medical Oncology, University Hospital, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> Medical Oncology, University Hospital, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Walter" sort="Weber, Walter" uniqKey="Weber W" first="Walter" last="Weber">Walter Weber</name><affiliation wicri:level="1"><nlm:aff id="A16"> Medical Oncology, University Hospital, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> Medical Oncology, University Hospital, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="A17"> CRC Genetic Epidemiology Unit, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> CRC Genetic Epidemiology Unit, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Dudakia, Darshna" sort="Dudakia, Darshna" uniqKey="Dudakia D" first="Darshna" last="Dudakia">Darshna Dudakia</name><affiliation wicri:level="1"><nlm:aff id="A18"> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Huddart, Robert" sort="Huddart, Robert" uniqKey="Huddart R" first="Robert" last="Huddart">Robert Huddart</name><affiliation wicri:level="1"><nlm:aff id="A19"> Academic Radiotherapy Unit, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Academic Radiotherapy Unit, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><affiliation wicri:level="1"><nlm:aff id="A18"> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Einhorn, Lawrence" sort="Einhorn, Lawrence" uniqKey="Einhorn L" first="Lawrence" last="Einhorn">Lawrence Einhorn</name><affiliation wicri:level="1"><nlm:aff id="A20"> Department of Medicine, Indiana University School of Medicine, Indianapolis, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Medicine, Indiana University School of Medicine, Indianapolis</wicri:regionArea><wicri:noRegion>Indianapolis</wicri:noRegion></affiliation></author><author><name sortKey="Korde, Larissa" sort="Korde, Larissa" uniqKey="Korde L" first="Larissa" last="Korde">Larissa Korde</name><affiliation wicri:level="2"><nlm:aff id="A1"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="2"><nlm:aff id="A21"> Division of Medical Genetics, Department of Medicine, University of Pennsylvania School of Medicine, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Medical Genetics, Department of Medicine, University of Pennsylvania School of Medicine, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><affiliation wicri:level="1"><nlm:aff id="A22"> Imperial Cancer Research Fund Genetic Epidemiology Lab, Ashley Wing, Leeds, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Imperial Cancer Research Fund Genetic Epidemiology Lab, Ashley Wing, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Rapley, Elizabeth A" sort="Rapley, Elizabeth A" uniqKey="Rapley E" first="Elizabeth A." last="Rapley">Elizabeth A. Rapley</name><affiliation wicri:level="1"><nlm:aff id="A18"> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation wicri:level="2"><nlm:aff id="A1"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">Urologic oncology</title><idno type="ISSN">1078-1439</idno><idno type="eISSN">1873-2496</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec id="S14"><title>Objectives</title><p id="P2">Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.</p></sec><sec sec-type="materials|methods" id="S15"><title>Materials and Methods</title><p id="P3">Families with ≥2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.</p></sec><sec id="S16"><title>Results</title><p id="P4">A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P=0.001). Among individuals with a history of cryptorchidism, TGCT was more likely to occur in the ipsilateral testis (kappa=0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.</p></sec><sec id="S17"><title>Conclusions</title><p id="P5">Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for non-familial cases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>France</li><li>Hongrie</li><li>Irlande (pays)</li><li>Norvège</li><li>Nouvelle-Zélande</li><li>Royaume-Uni</li><li>Russie</li><li>République tchèque</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bohême centrale</li><li>District de Kassel</li><li>District fédéral central</li><li>Hesse (Land)</li><li>Hongrie centrale</li><li>Hovedstaden</li><li>Maryland</li><li>Nouvelle-Galles du Sud</li><li>Ontario</li><li>Pennsylvanie</li><li>Østlandet</li></region><settlement><li>Budapest</li><li>Cassel (Hesse)</li><li>Copenhague</li><li>Moscou</li><li>Oslo</li><li>Prague</li><li>Sydney</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name></region><name sortKey="Einhorn, Lawrence" sort="Einhorn, Lawrence" uniqKey="Einhorn L" first="Lawrence" last="Einhorn">Lawrence Einhorn</name><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><name sortKey="Korde, Larissa" sort="Korde, Larissa" uniqKey="Korde L" first="Larissa" last="Korde">Larissa Korde</name><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name></region><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><name sortKey="Tucker, Kathy" sort="Tucker, Kathy" uniqKey="Tucker K" first="Kathy" last="Tucker">Kathy Tucker</name></country><country name="Canada"><region name="Ontario"><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name></region><name sortKey="Jewett, Michael A S" sort="Jewett, Michael A S" uniqKey="Jewett M" first="Michael A. S." last="Jewett">Michael A. S. 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Tjulandin</name></country><country name="Suisse"><noRegion><name sortKey="Stoll, Hans" sort="Stoll, Hans" uniqKey="Stoll H" first="Hans" last="Stoll">Hans Stoll</name></noRegion><name sortKey="Weber, Walter" sort="Weber, Walter" uniqKey="Weber W" first="Walter" last="Weber">Walter Weber</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name></noRegion><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><name sortKey="Dudakia, Darshna" sort="Dudakia, Darshna" uniqKey="Dudakia D" first="Darshna" last="Dudakia">Darshna Dudakia</name><name sortKey="Huddart, Robert" sort="Huddart, Robert" uniqKey="Huddart R" first="Robert" last="Huddart">Robert Huddart</name><name sortKey="Rapley, Elizabeth A" sort="Rapley, Elizabeth A" uniqKey="Rapley E" first="Elizabeth A." last="Rapley">Elizabeth A. Rapley</name><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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